COMBINE 2010
Informatics Forum, University of Edinburgh
Edinburgh, Scotland
Oct. 6–9, 2010
In 2010, we inaugurated a new, broader series of meetings to replace, among other events, the SBML and SBGN forums. The new meetings are a recognition of the fact that there are multiple allied standardization efforts that should work together towards smooth interoperability. Moreover, we believe a joint meeting makes good economic sense: compared to multiple separate workshops, they reduce the overall number of meetings, travel, and money spent over the year. To reflect its broad scope, we have called the new workshop series the annual meeting of COMBINE:
the COmputational Modeling in BIology NEtwork
COMBINE 2010 took place on October 6–9, 2010, immediately before ICSB 2010, in Edinburgh, Scotland. The final session of COMBINE (October 9, 2010) was followed by a special event to mark the 10th anniversary of SBML.
Agenda
The activities at COMBINE meetings are similar to typical workshops, with oral and poster presentations, break-out discussions, and more. The following table summarizes the organization of the 2010 event across the four days. A detailed agenda appears below.
| Wednesday 6th | Thursday 7th | Friday 8th | Saturday 9th | |
|---|---|---|---|---|
| Session 1 | Physiome languages | Graphical layout and rendering | Format conversion | SBML Level 3 |
| break | ||||
| Session 2 | SED-ML | Interactions and Reactions | Multi-standard software | libSBML and SBML support |
| lunch | ||||
| Session 3 | SBGN languages | Semantics and metadata resources | BioPAX status and future directions | |
| break | SBML 10th Anniversary | |||
| Session 4 | libSBGN and SBGN support | Encoding and using semantics | Gaps in coverage and concepts |
|
In addition to being available for downloading from below, many of the presentations and the posters are now part of the Nature Precedings COMBINE 2010 collection.
Wednesday, October 6
| Time | Topic | Speaker/Leader | Files | Recordings |
|---|---|---|---|---|
| 09:00–09:30 | Registration, coffee | |||
| 09:30–10:00 | Welcome, introduction to COMBINE 2010 | Nicolas Le Novère | Slides | Video |
| Stuart Moodie | Slides | Video | ||
| 10:00–11:30 | Physiome languages (main room) | chair: Peter Hunter | ||
| "Intro. PMR2" | Peter Hunter | Slides | Video | |
| "CellML 1.1 modularity" | Poul Nielsen | Slides | Video | |
| "Workflows/GUI interfaces (nephron model), linking CellML to fields thru FieldML" | David Nickerson | Slides | Video | |
| "OpenCell, status and plans" | Alan Garny | Slides | Video | |
| Discussion | Video | |||
| 10:00–11:30 | breakouts | |||
| 11:30–12:00 | Coffee break | |||
| 12:00–13:30 | SED-ML (main room) | chair: Frank T. Bergmann | ||
| "Intro to the session, libsedml" | Frank T. Bergmann | Slides | Video | |
| "jlibsedml and its application in SBSI" | Richard Adams | Slides | Video | |
| "jlibsedml utility functions" | Ion Moraru | Slides | Video | |
| Discussion | Video | |||
| 12:00–13:30 | breakouts | |||
| 13:30–14:30 | Lunch | |||
| 14:30–16:00 | SBGN languages (main room) | chair: Stuart Moodie | Video | |
| 14:30 | ""Report on the status of SBGN ER and proposed extensions." | Nicolas Le Novère | Slides | Video |
| 14:45 | "SBGN PD: current status, future changes and unresolved issues." | Stuart Moodie | Slides | Video |
| 15:00 | "Update on SBGN-AF" | Huaiyu Mi | Slides | Video |
| 15:15 | "SBGN-ER for physiology mechanisms." | Bernard de Bono | Slides | Video |
| Discussion | Video | |||
| SBGN Awards | Video | |||
| 14:30–16:00 | breakouts | |||
| 16:00–16:30 | Coffee break | |||
| 16:30–18:00 | libSBGN and SBGN support (main room) | chair: Alice Villeger | Video | |
| "LibSBGN: current status and future plans" | Alice Villeger | Slides | Video | |
| "SBGN-ED for Editing, Validating, and Translating of SBGN Maps and Application Examples" | Tobias Czauderna | Slides | Video | |
| "SBGN support in BIOCHAM" | Dragana Jovanovska | Slides | Video | |
| Discussion | Video | |||
| 16:30–18:00 | breakouts | |||
Thursday, October 7
| Time | Topic | Speaker/Leader | Files | Recordings |
|---|---|---|---|---|
| 08:30–09:00 | Welcome, introduction to the day | |||
| 09:00–10:30 | Graphical layout and rendering (main room) | chair: Ralph Gauges | ||
| "SBML layout and render news" | Ralph Gauges | Slides | Video | |
| "BioPAX support in CellDesigner" | Huaiyu Mi | Slides | Video | |
| "Encoding and exchanging graphical representation: architecture and formats" | Andrei Zinovyev for Fedor Kolpakov | Slides | Video | |
| Discussion | Video | |||
| 09:00–10:30 | breakouts | |||
| 10:30–11:00 | Coffee break | |||
| 11:00–12:30 | Interactions and reactions (main room) | chair: Henning Hermjakob | ||
| "The HUPO Proteomics Standards Initiative" | Henning Hermjakob | Slides | Video | |
| "Exchanging experimental kinetic data via SabioML" | Martin Golebiewski | Slides | Video | |
| Pathways Integration | Emek Demir | Slides | Video | |
| "The Reactome Pathway Database; its functionality and data exchange formats" | David Croft | Slides | Video | |
| 11:00–12:30 | breakouts | |||
| 12:30–13:30 | Lunch | |||
| 13:30–15:00 | Semantics and metadata resources (main room) | chair: Camille Laibe | ||
| "Systems Biology Ontology: Update" | Nick Juty | Slides | Video | |
| "MIRIAM Resources: next steps" | Camille Laibe | Slides | Video | |
| "about BioPAX and RDF" | Andrea Splendiani | Slides | Video | |
| Discussion | Video | |||
| 13:30–15:00 | breakouts | |||
| 15:00–15:30 | Coffee break | |||
| 15:30–17:00 | Encoding and using semantics (main room) | chair: Neil Swainston | Video | |
| "Ranked retrieval of annotated models" | Ron Henkel | Slides | Video | |
| "The SBML Level 3 Annotation package: an initial proposal" | Neil Swainston | Slides | Video | |
| "Model search and parameter balancing in semanticSBML" | Wolfram Liebermeister | slides | Video | |
| Discussion | Video | |||
| 15:30–17:00 | breakouts | |||
| 19:30 | Dinner at "Wee Windaes" (partially self-funded) | |||
Friday, October 8
| Time | Topic | Speaker/Leader | Files | Recordings |
|---|---|---|---|---|
| 08:30–09:00 | Welcome, introduction to the day | |||
| 09:00–10:30 | Format conversion (main room) | chair: Martijn Van Iersel | ||
| "Collaborative pathway editing & analysis with WikiPathways and PathVisio" | Martijn van Iersel | Slides | Video | |
| "The General Converter Package" | Jean-Baptiste Pettit | Slides | Video | |
| "Insights in SBML Interoperability and Interconversion" | Alice Villéger | Slides | Video | |
| 09:00–10:30 | breakouts | |||
| 10:30–11:00 | Coffee break | |||
| 11:00–12:30 | Multi-standard software (main room) | chair: Lucian Smith | ||
| "Tales from the Code Front: Translating Modularity" | Lucian Smith | Slides | Video | |
| "BioModels Database: next generation model repository" | Camille Laibe and Michael Hoehl | Slides | Video | |
| "The PSI Common Query Interface (PSICQUIC) - Standard API for 12 interaction databases" | Henning Hermjakob | Slides | Video | |
| "Software for Molecular Interaction Maps (MIMs): Editor, API, and Validation" | Augustin Luna | Slides | Video | |
| "BiNoM Cytoscape Plugin for constructing, quering and analyzing biological networks, using systems biology standards" | Andrei Zinovyev | Slides | Video | |
| "BioUML integrated platform for building virtual cell and virtual physiological human" | Andrei Zinovyev for Fedor Kolpakov | Slides | Video | |
| 11:00–12:30 | breakouts | |||
| 12:30–13:30 | Lunch | |||
| 13:30–15:00 | BioPAX status and future directions (main room) | chair: Emek Demir | Audio | |
| "Overview of BioPAX", discussion | Nadia Anwar | Audio | ||
| "BioPAX L2 and L3" | Emek Demir | Slides | Video (1) | |
| "Community update and structure", "Workgroups Priorities" | Nadia Anwar | Slides | Video | |
| "The Future of BioPAX" | Gary Bader | Slides | n/a | |
| "Layout Workgroup" | Martijn van Iersel | Slides | n/a | |
| "BioPAX L4 Proposals" | Emek Demir | Slides | Video (2) | |
| 13:30–15:00 | breakouts | |||
| 15:00–15:30 | Coffee break | |||
| 15:30–17:00 | Gaps in coverage and concepts (main room) | chair: Robert Cannon | ||
| "Towards a comprehensive set of descriptive standards for biology" | Nicolas Le Novère | Slides | Video | |
| "Types, models and instances: a perspective from neuroscience" | Robert Cannon | Slides | Video | |
| "Metabolic network representation in SBGN PD: EC and identity gate." | Alexander Mazein | Slides | Video | |
| "A generic approach for representing complex structures in biological models" | Robert Muetzelfeldt | Slides | Video | |
| "Exploring the challenges of pathway depiction and the development of modified Edinburgh Pathway Notation (mEPN) scheme" | Tom Freeman | Slides | Video | |
| 15:30–17:00 | breakouts | |||
- (1) This presentation begins with audio only. Video begins partway through.
- (2) Audio and video begin partway through the presentation.
Saturday, October 9
| Time | Topic | Speaker/Leader | Files | Recordings |
|---|---|---|---|---|
| 08:30–09:00 | Welcome, introduction to the day | |||
| 09:00–10:30 | SBML Level 3 (main room) | chair: Mike Hucka | ||
| "SBML Level 3 Update" | Mike Hucka | Slides | Video | |
| "The SBML Level 3 Spatial Package" | James Schaff | Slides | Video | |
| "The SBML Flux Balance Analysis Package" | Brett Olivier | Slides | Video | |
| "The SBML Hierarchical Composition Package" | Lucian Smith | Slides | Video (3) | |
| 09:00–10:30 | breakouts | |||
| 10:30–11:00 | Coffee break | |||
| 11:00–12:30 | libSBML and SBML support (main room) | chair: Sarah Keating | ||
| "Update on libSBML status" | Sarah Keating | Slides | Video | |
| "Implementation of L3 Support within iBioSim" | Chris Myers | Slides | Video | |
| "Update on JSBML status" | Nicolas Rodriguez | Slides | Video | |
| "Context-based generation of kinetic equations with SBMLsqueezer 1.3 " | Andreas Draeger | Slides | Video | |
| 11:00–12:30 | breakouts | |||
| 12:30–13:30 | Lunch |
- (3) The video ends before the end of the talk. However, the audio continues throughout.
Posters
COMBINE 2010 offered the opportunity for attendees to display posters. This served as a means for people to inform each other about their software and other projects in a setting that allowed interaction and in-depth discussion.
The maximum poster size was A0, which is 841mm (width) x 1189mm (height), or approximately 33in x 46in, in a portrait orientation. This was essentially the same size as the ICSB 2010 posters.
Poster sessions were held semi-concurrently with lunch breaks. The basic approach was to make the breaks extra long, so that people could get some food & beverages, then come back and discuss their work in the poster room.
Location
The meeting was held in the Informatics Forum building at the University of Edinburgh. This is a new center for innovation and interaction—ideally suited to the goals of COMBINE. This venue is located in the centre of the University's main campus.
Informatics Forum
Room G07
University of Edinburgh
10 Crichton Street
Edinburgh, EH8 9AB
Scotland, United Kingdom
Funding Acknowledgments
Support for COMBINE 2010 was provided by the following organizations:
| Biotechnology and Biological Sciences Research Council | | ![]() |
Organization
COMBINE 2010 was organized by the following people (listed in alphabetical order):
- Nadia Anwar, Memorial Sloan-Kettering Cancer Center (USA)
- Emek Demir, Memorial Sloan-Kettering Cancer Center (USA)
- Michael Hucka, California Institute of Technology (USA)
- Camille Laibe, European Bioinformatics Institute (EMBL-EBI, UK)
- Nicolas Le Novère, European Bioinformatics Institute (EMBL-EBI, UK)
- Catherine Lloyd, Auckland Bioengineering Institute (New Zealand)
- Stuart Moodie, University of Edinburgh (UK)
- Anatoly Sorokin, University of Edinburgh (UK)
For general information about the meeting, and travel arrangements for the speakers of October 9th, contacts were:
| Linda Taddeo | Michael Hucka | Nicolas Le Novère |
|---|---|---|
| ltaddeo at caltech.edu | mhucka at caltech.edu | lenov at ebi.ac.uk |
| Tel: +1 626 395 3375 | Tel: +1 626 395 6911 | Tel: +44 1223 494 521 |
| Beckman Institute 139-74 California Institute of Technology Pasadena, California 91125 USA | EMBL-EBI Wellcome-Trust Genome Campus Hinxton, CB10 1SD UK | |
For practical information on the setting and local organisation, contacts were:
| Stuart Moodie | Anatoly Sorokin | Fiona Clark |
|---|---|---|
| stuart.moodie at ed.ac.uk | asorokin at inf.ed.ac.uk | fclark1 at inf.ed.ac.uk |
| Tel: +44 1316 513 291 | ||
| School of Informatics, Informatics Forum University of Edinburgh | ||





