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Hello,

Imagine there is a model available (be it from the BioModels DB or
from a friendly colleague) that fits your purpose - almost. You just
need to tweak it a little bit, maybe add two species and a reaction,
or remove or replace something.

Are the annotations that were present in the original model still
valid in the new model?

Since any one can add their own types annotations, no SBML editing
tool can be expected to understand and verify them all. If they are
simply left unchanged, they may say something about the model that is
not true in the tweaked version. Does that mean all annotations the
editing tool does not understand have to be dropped if a model is
changed?

Do annotations have something like a scope, so that they are only
invalidated by changes inside the scope?

Take care
Oliver

--
Oliver Ruebenacker, Computational Cell Biologist
Systems Biology Linker at Virtual Cell (http://vcell.org/sybil)
Turning Knowledge Data into Models
Center for Cell Analysis and Modeling
http://www.oliver.curiousworld.org
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