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To SBML Developers,
is spatially heterogeneous modeling currently possible in SBML? From my preliminary searches it does not seem to be the case but I wonder if there are workarounds using Rules and SBML Events. I am primarily basing this from this http://sbml.org/images/7/70/20071005-schaff-spatialmodeling.pdf.

Since I am looking at the glycosylation process within the Golgi, I need to be able to vary my enzyme concentrations depending on how far I move along the Golgi, i.e. certain enzymes are in higher concentrations at the entry whereas others are in higher concentrations closer to the exit. I do realize that one workaround would be to separate these heterogeneous zones into compartments. However, this adds multiple unknown parameters that contribute to a ballooning parameter estimation problem. Further, recent literature suggests that the Golgi itself matures and the enzymes undergo retrograde transport which cannot be accurately modeled using several compartments.

I have a functional model built in MATLAB, but I greatly favor the mobility that SBML provides.