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Hello,

If we have a reaction network and we know some, but not all kinetic
parameters and (initial) concentrations, what is the best we can do
with it?

- If we know all initial concentrations and kinetic parameters, we
can do kinetic modeling (i.e. time-course)
- If we know all kinetic parameters, we can try to find steady-states
- If the only numbers we know are the stoichiometric coefficients,
we still can do flux balance analysis and constraint-based modeling

The more typical scenario is, that we know some, but not all, of the
kinetic parameters, and some, but not all, of the (initial)
concentrations.

Does any one know of work being done on this? Perhaps a hybrid of
the above approaches?

Thanks!

Take care
Oliver

--
Oliver Ruebenacker
Bioinformatics Consultant (http://www.knowomics.com/wiki/Oliver_Ruebenacker)
Knowomics, The Bioinformatics Network (http://www.knowomics.com)
SBPAX: Turning Bio Knowledge into Math Models (http://www.sbpax.org)
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