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Oliver,

In Manchester we work on this. We've published so far two papers on
this, a couple of new ones are in preparation...

Kieran Smallbone, Evangelos Simeonidis, David S Broomhead, Douglas B
Kell (2007) Something from nothing− bridging the gap between
constraint‐based and kinetic modelling. FEBS J. 274, 5576-5585
http://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2007.06076.x/full

K Smallbone, E Simeonidis, N Swainston, P Mendes (2010) Towards a
genome-scale kinetic model of cellular metabolism. BMC systems biology 4, 6
http://www.biomedcentral.com/1752-0509/4/6/


On 05/28/2012 12:31 PM, Oliver Ruebenacker wrote:
>[...]
> The more typical scenario is, that we know some, but not all, of the
> kinetic parameters, and some, but not all, of the (initial)
> concentrations.
>
> Does any one know of work being done on this? Perhaps a hybrid of
> the above approaches?


--
Pedro Mendes
Professor of Computational Systems Biology
School of Computer Science
Manchester Centre for Integrative Systems Biology
University of Manchester

Manchester Interdisciplinary Biocentre
131 Princess Street
Manchester, M1 7DN, U.K.
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