Rainer Machne wrote:
> Nicolas Le novère wrote:
>>> | dx/dt = k * C * Y / (K + Y) | where C = [calcium/calmodulin]/[total
>>> calmodulin]
> They are all in concentration units though, and the derived entities
> could as well be defined as "species" in another model's context: this
> should be the modeler's choice.
No they are not. C is dimensionless and can only take values from 0 to 1.
>> Sorry, but if there are no kineticLaw, the concept of modifier is moot.
>> Even if the modifier was listed, the reaction would be "incompletely
>> specified".
>>
>> Reactant A
>> Product B
>> Modifier C and D
>>
>> What does that mean? What is the effect of C and B? Are they stimulators?
>> Inhibitors? Neutral? Have opposite effect?
>
> Actually that could be quite common: the exact kinetics are not known
> yet, but the modifiers are (is it competitive or non-competitive
> inhibition e.g.). And thus the modeler leaves kinetic law empty, e.g.
> for other software to infer the exact form of the kinetic law from
> measurements.
I am not talking about mathematics. There is nothing that says "inhibitor".
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| 
06 Aug '08 10:45
