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Folks

Ah I got caught by my own double negative.

I wrote:

> > however this doesn't mean that more than one set of parameters is
> > meaningful for the same model.

I meant:

more than one set of parameters is meaningful for the same model

Sorry for the confusion

Thanks Martin

yours Andrew

> -----Original Message-----
> From: ginkel@pc111.mpi-magdeburg.mpg.de
> [mailto:ginkel@pc111.mpi-magdeburg.mpg.de] On Behalf Of Martin Ginkel
> Sent: 09 December 2002 10:43
> To: Andrew Finney
> Cc: sbml-discuss@symbio.jst.go.jp
> Subject: RE: [sbml-discuss] thoughts on models and and model
> parameters
>
>
>
> Hi,
>
> On 09-Dec-2002 Andrew Finney wrote:
> >>parameter sets only
> >>exist in the context of a model.
>
> I aggree to this, but...
>
> > however this doesn't mean that more than one set of parameters is
> > meaningful for the same model. In fact this becomes a very
> meaningful
> > way to represent mutants.
> >
> > An additional application (which might be close to Pedro's
> heart) is
> > using parameter sets to store the results of different parameter
> > optimisation/fitting runs on the same model.
>
> Especially for this it becomes meaningful, because for
> fitting you often use different experimental results, perturbing the
> model and the cells with different conditions and initial
> values. (feeding conditions, mutants with switched off
> pathways etc.) All this parameters can be applied to _a
> family of models_
> (model variants e.g. for hypothesis test).
>
> Martin
>
> --
> +-[Martin
> Ginkel]--------------[mailto:ginkel(at)mpi-magdeburg.mpg.de]-+
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