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Posts: 469
Registered: October 2003
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RE: Suggestion for new section in SBML
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11 Feb '06 17:14

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> Membrane potential (Vm). Clearly can be expected to change with time, but
> just as clearly is not a Species. Some models obtain Vm by keeping track
> of
> the charge on the membrane capacitance. This is then an algebraic rule
> giving Vm = Q/C and the variation in time arises because the charged
> species that make up Q are changing. In this case no initial condition is
> required since the initial value of Vm is determined by the initial values
> of the charged species. Other models write dVm/dt = i/C and the time
> dependence arises from changing membrane currents that make up the total
> current, i. In either case Vm is time varying, but in neither case is it
> obvious to me how to encode it in SBML.
It is encoded as a rate-rule in the Hodgkin-Huxley we have in BioModels DB
(It originally comes form CellML repository I think)
http://www.ebi.ac.uk/compneur-srv/biomodels-main/publ-model.do?mid=BIOMD0000000020
--
Nicolas LE NOVÈRE, Computational Neurobiology,
EMBL-EBI, Wellcome-Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
Tel: +44(0)1223 494 521, Fax: +44(0)1223 494 468, Mob: +33(0)689218676
http://www.ebi.ac.uk/~lenov
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