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Ouch! The reversible flag has a very clear meaning, and is essential
for various treatments (graphical output, treatment of fast reactions
where one ignore kineticLaws etc).

I am probably misunderstanding the issue here, but you can just define
two reactions as Herbert says BUT set the reversible flag to
"false". It is true by default.

Remind-me why can't you use a reversible reaction with a kineticLaw of
the form

kon * react - koff * prod

?

On Thu, 9 Mar 2006, Bill Denney wrote:

> This is what I've been doing, but it doesn't really seem like the best
> solution, and I was thinking this would be a place where the standard could
> use some improvement. I didn't know why the flag was there-- it seems a bit
> specific (and it could be detected other ways).
>
> Bill
>
> On Thu, 9 Mar 2006, Herbert Sauro wrote:
>
>> In this situtation I would simply define two reactions, one for the on
>> rate and one for the off rate. Ignore the reversibility flag, it was
>> originally intended to be used in elemetnary mode and flux balance
>> analysis.
>>
>> Herbert Sauro
>>
>> -----Original Message-----
>> From: Bill Denney [mailto:denney@seas.upenn.edu]
>> Sent: Thursday, March 09, 2006 10:15 AM
>> To: sbml-discuss@caltech.edu
>> Subject: [sbml-discuss] Multiple kineticLaw Sections Per Reaction
>>
>> I'm wanting to put multiple kineticlaw sections in each reaction. The
>> reason that I want to do this is because I have kinetic data on both the
>> on and off rates of the reactions that I need to model as separate
>> reactions. I thought that it made sense that if I said that the
>> reaction was reversible then I could have both the forward and reverse
>> kinetics within that reaction.
>>
>> Something similar to this seems to have been discussed before:
>> http://www.sbml.org/forums/index.php?t=tree&goto=2996&rid=0
>>
>> Is there a better, more accepted way to do this?
>>
>> Another issue that I've been thinking about is: what is the best way to
>> store multiple values for the same kinetic rate constants. The reason I
>> want to do this is that I have tables that list a set of kinetics for
>> reactions from several groups that may not agree. I would like to store
>> all these values within my sbml so that my tools can try to enumerate
>> which kinetics seem to be the most consistent. I could do this within
>> an annotation, but it seems as though it could be an issue that could
>> more generally useful to the sbml community.
>>
>> Bill
>>
>> --
>> Emily's Lullaby n. - A tranquilizer dart.
>> -- Will Miller
>>
>
>

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Nicolas LE NOVERE, Computational Neurobiology,
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