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> It would allow the reactions, for the stochastic simulators among us, to
> be specified in a more logical manner, and presumably, it would allow for
> elementary mode analysis to perform better when reactions are specified as
> actually being reversible instead of two irreversible reactions (I
> assume-- I'm not familiar with elementary mode analysis).

But .... any reversible reaction IS in fact the sum of two irreversible
reactions.

You mentioned stochastic simulations. But you are only talking about
population-based stochastic simulations. If you use particle-based
approaches, the on and off reactions are obligatory uncoupled. The
reversibility is only an averaged phenotype of the whole populations.

> Finally, it
> would allow graphics packages to easily and correctly recognise and
> display reversible reactions.

Well, if I have two reactions A->B and B->A with the same modifier(s), the
reconstruction is not hugely difficult.

--
Nicolas LE NOVÈRE, Computational Neurobiology,
EMBL-EBI, Wellcome-Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
Tel: +44(0)1223 494 521, Fax: +44(0)1223 494 468, Mob: +33(0)689218676
http://www.ebi.ac.uk/~lenov