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   <p>This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2006 The BioModels Team.<br/>For more information see the<a href="http://www.ebi.ac.uk/biomodels/legal.html">terms of use</a>.</p>
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     <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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    <annotation>
     <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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         <rdf:li rdf:resource="http://www.geneontology.org/#GO:0008349"/>
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        </rdf:Bag>
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     <speciesReference species="MKKK"/>
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    <listOfProducts>
     <speciesReference species="MKKK_P"/>
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    <listOfModifiers>
     <modifierSpeciesReference species="MAPK_PP"/>
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    <kineticLaw>
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      <apply>
       <divide/>
       <apply>
        <times/>
        <ci>uVol</ci>
        <ci>V1</ci>
        <ci>MKKK</ci>
       </apply>
       <apply>
        <times/>
        <apply>
         <plus/>
         <cn type="integer">1</cn>
         <apply>
          <power/>
          <apply>
           <divide/>
           <ci>MAPK_PP</ci>
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          </apply>
          <ci>n</ci>
         </apply>
        </apply>
        <apply>
         <plus/>
         <ci>K1</ci>
         <ci>MKKK</ci>
        </apply>
       </apply>
      </apply>
     </math>
     <listOfParameters>
      <parameter id="V1" value="2.5"/>
      <parameter id="Ki" value="9"/>
      <parameter id="n" value="1"/>
      <parameter id="K1" value="10"/>
     </listOfParameters>
    </kineticLaw>
   </reaction>
   <reaction metaid="_584655" id="J1" name="MAPKKK inactivation" reversible="false">
    <annotation>
     <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
      <rdf:Description rdf:about="#_584655">
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        <rdf:Bag>
         <rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#3.1.3.16"/>
         <rdf:li rdf:resource="http://www.geneontology.org/#GO:0006470"/>
         <rdf:li rdf:resource="http://www.geneontology.org/#GO:0051390"/>
        </rdf:Bag>
       </bqbiol:isVersionOf>
      </rdf:Description>
     </rdf:RDF>
    </annotation>
    <listOfReactants>
     <speciesReference species="MKKK_P"/>
    </listOfReactants>
    <listOfProducts>
     <speciesReference species="MKKK"/>
    </listOfProducts>
    <kineticLaw>
     <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
       <divide/>
       <apply>
        <times/>
        <ci>uVol</ci>
        <ci>V2</ci>
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       <apply>
        <plus/>
        <ci>KK2</ci>
        <ci>MKKK_P</ci>
       </apply>
      </apply>
     </math>
     <listOfParameters>
      <parameter id="V2" value="0.25"/>
      <parameter id="KK2" value="8"/>
     </listOfParameters>
    </kineticLaw>
   </reaction>
   <reaction metaid="_584675" id="J2" name="phosphorylation of MAPKK" reversible="false">
    <annotation>
     <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
      <rdf:Description rdf:about="#_584675">
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        <rdf:Bag>
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        </rdf:Bag>
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     </rdf:RDF>
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    <listOfReactants>
     <speciesReference species="MKK"/>
    </listOfReactants>
    <listOfProducts>
     <speciesReference species="MKK_P"/>
    </listOfProducts>
    <listOfModifiers>
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        <ci>MKK</ci>
       </apply>
       <apply>
        <plus/>
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        <ci>MKK</ci>
       </apply>
      </apply>
     </math>
     <listOfParameters>
      <parameter id="k3" value="0.025"/>
      <parameter id="KK3" value="15"/>
     </listOfParameters>
    </kineticLaw>
   </reaction>
   <reaction metaid="_584695" id="J3" name="phosphorylation of MAPKK-P" reversible="false">
    <annotation>
     <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
      <rdf:Description rdf:about="#_584695">
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        <rdf:Bag>
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        <rdf:Bag>
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     <speciesReference species="MKK_P"/>
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    <listOfProducts>
     <speciesReference species="MKK_PP"/>
    </listOfProducts>
    <listOfModifiers>
     <modifierSpeciesReference species="MKKK_P"/>
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    <kineticLaw>
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      <apply>
       <divide/>
       <apply>
        <times/>
        <ci>uVol</ci>
        <ci>k4</ci>
        <ci>MKKK_P</ci>
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       </apply>
       <apply>
        <plus/>
        <ci>KK4</ci>
        <ci>MKK_P</ci>
       </apply>
      </apply>
     </math>
     <listOfParameters>
      <parameter id="k4" value="0.025"/>
      <parameter id="KK4" value="15"/>
     </listOfParameters>
    </kineticLaw>
   </reaction>
   <reaction metaid="_584715" id="J4" name="dephosphorylation of MAPKK-PP" reversible="false">
    <annotation>
     <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
      <rdf:Description rdf:about="#_584715">
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    </annotation>
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       <apply>
        <plus/>
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     </math>
     <listOfParameters>
      <parameter id="V5" value="0.75"/>
      <parameter id="KK5" value="15"/>
     </listOfParameters>
    </kineticLaw>
   </reaction>
   <reaction metaid="_584735" id="J5" name="dephosphorylation of MAPKK-P" reversible="false">
    <annotation>
     <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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    <listOfProducts>
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      <apply>
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        <times/>
        <ci>uVol</ci>
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       <apply>
        <plus/>
        <ci>KK6</ci>
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       </apply>
      </apply>
     </math>
     <listOfParameters>
      <parameter id="V6" value="0.75"/>
      <parameter id="KK6" value="15"/>
     </listOfParameters>
    </kineticLaw>
   </reaction>
   <reaction metaid="_584755" id="J6" name="phosphorylation of MAPK" reversible="false">
    <annotation>
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    <listOfProducts>
     <speciesReference species="MAPK_P"/>
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    <listOfModifiers>
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    <kineticLaw>
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      <apply>
       <divide/>
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        <times/>
        <ci>uVol</ci>
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        <ci>MKK_PP</ci>
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       </apply>
       <apply>
        <plus/>
        <ci>KK7</ci>
        <ci>MAPK</ci>
       </apply>
      </apply>
     </math>
     <listOfParameters>
      <parameter id="k7" value="0.025"/>
      <parameter id="KK7" value="15"/>
     </listOfParameters>
    </kineticLaw>
   </reaction>
   <reaction metaid="_584775" id="J7" name="phosphorylation of MAPK-P" reversible="false">
    <annotation>
     <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
      <rdf:Description rdf:about="#_584775">
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    <listOfReactants>
     <speciesReference species="MAPK_P"/>
    </listOfReactants>
    <listOfProducts>
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    <listOfModifiers>
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    <kineticLaw>
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      <apply>
       <divide/>
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        <times/>
        <ci>uVol</ci>
        <ci>k8</ci>
        <ci>MKK_PP</ci>
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       </apply>
       <apply>
        <plus/>
        <ci>KK8</ci>
        <ci>MAPK_P</ci>
       </apply>
      </apply>
     </math>
     <listOfParameters>
      <parameter id="k8" value="0.025"/>
      <parameter id="KK8" value="15"/>
     </listOfParameters>
    </kineticLaw>
   </reaction>
   <reaction metaid="_584795" id="J8" name="dephosphorylation of MAPK-PP" reversible="false">
    <annotation>
     <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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    </annotation>
    <listOfReactants>
     <speciesReference species="MAPK_PP"/>
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      <apply>
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        <ci>uVol</ci>
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       <apply>
        <plus/>
        <ci>KK9</ci>
        <ci>MAPK_PP</ci>
       </apply>
      </apply>
     </math>
     <listOfParameters>
      <parameter id="V9" value="0.5"/>
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     </listOfParameters>
    </kineticLaw>
   </reaction>
   <reaction metaid="_584815" id="J9" name="dephosphorylation of MAPK-P" reversible="false">
    <annotation>
     <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
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    </annotation>
    <listOfReactants>
     <speciesReference species="MAPK_P"/>
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    <listOfProducts>
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    <kineticLaw>
     <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
       <divide/>
       <apply>
        <times/>
        <ci>uVol</ci>
        <ci>V10</ci>
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       <apply>
        <plus/>
        <ci>KK10</ci>
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       </apply>
      </apply>
     </math>
     <listOfParameters>
      <parameter id="V10" value="0.5"/>
      <parameter id="KK10" value="15"/>
     </listOfParameters>
    </kineticLaw>
   </reaction>
  </listOfReactions>
 </model>
</sbml>
