<?xml version="1.0" encoding="UTF-8"?;>
<!-- Generated 27-February-2004 18:42:01.020248 -->
<!-- Generated by MathSBML 2.2.1-beta-17 (25-Feb-2004) -->
<sbml xmlns="http://www.sbml.org/sbml/level2"
level="2"
version="1">
<model id="MAPK"
name="MAPK with feedback [Kholodenko,2000]">
<listOfFunctionDefinitions/>
<listOfUnitDefinitions/>
<listOfCompartments>
<compartment id="uVol"
name="uVol"/>
</listOfCompartments>
<listOfSpecies>
<species id="KKK"
name="KKK"
compartment="uVol"
boundaryCondition="false"
constant="false"
initialAmount="90"/>
<species id="KKKp"
name="KKKp"
compartment="uVol"
boundaryCondition="false"
constant="false"
initialAmount="10"/>
<species id="KK"
name="KK"
compartment="uVol"
boundaryCondition="false"
constant="false"
initialAmount="280"/>
<species id="KKp"
name="KKp"
compartment="uVol"
boundaryCondition="false"
constant="false"
initialAmount="10"/>
<species id="KKpp"
name="KKpp"
compartment="uVol"
boundaryCondition="false"
constant="false"
initialAmount="10"/>
<species id="K"
name="K"
compartment="uVol"
boundaryCondition="false"
constant="false"
initialAmount="280"/>
<species id="Kp"
name="Kp"
compartment="uVol"
boundaryCondition="false"
constant="false"
initialAmount="10"/>
<species id="Kpp"
name="Kpp"
compartment="uVol"
boundaryCondition="false"
constant="false"
initialAmount="10"/>
</listOfSpecies>
<listOfParameters/>
<listOfRules/>
<listOfReactions>
<reaction id="reaction1"
name="reaction1"
reversible="false"
fast="false">
<listOfReactants>
<speciesReference species="KKK"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="KKKp"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="Kpp"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci>KKK</ci>
<ci>V1</ci>
<apply>
<power/>
<apply>
<times/>
<apply>
<plus/>
<ci>K1</ci>
<ci>KKK</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<apply>
<times/>
<ci>Kpp</ci>
<apply>
<power/>
<ci>Ki</ci>
<cn type="integer">-1</cn>
</apply>
</apply>
<ci>n</ci>
</apply>
<cn type="integer">1</cn>
</apply>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="V1"
value="2.5"/>
<parameter id="Ki"
value="10"/>
<parameter id="n"
value="1"/>
<parameter id="K1"
value="10"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="reaction2"
name="reaction2"
reversible="false"
fast="false">
<listOfReactants>
<speciesReference species="KKKp"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="KKK"/>
</listOfProducts>
<listOfModifiers/>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci>KKKp</ci>
<ci>V2</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>KK2</ci>
<ci>KKKp</ci>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="V2"
value="0.25"/>
<parameter id="KK2"
value="8"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="reaction3"
name="reaction3"
reversible="false"
fast="false">
<listOfReactants>
<speciesReference species="KK"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="KKp"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="KKKp"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci>k3</ci>
<ci>KK</ci>
<ci>KKKp</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>KK</ci>
<ci>KK3</ci>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="k3"
value="0.025"/>
<parameter id="KK3"
value="15"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="reaction4"
name="reaction4"
reversible="false"
fast="false">
<listOfReactants>
<speciesReference species="KKp"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="KKpp"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="KKKp"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci>k4</ci>
<ci>KKKp</ci>
<ci>KKp</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>KK4</ci>
<ci>KKp</ci>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="k4"
value="0.025"/>
<parameter id="KK4"
value="15"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="reaction5"
name="reaction5"
reversible="false"
fast="false">
<listOfReactants>
<speciesReference species="KKpp"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="KKp"/>
</listOfProducts>
<listOfModifiers/>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci>KKpp</ci>
<ci>V5</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>KK5</ci>
<ci>KKpp</ci>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="V5"
value="0.75"/>
<parameter id="KK5"
value="15"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="reaction6"
name="reaction6"
reversible="false"
fast="false">
<listOfReactants>
<speciesReference species="KKp"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="KK"/>
</listOfProducts>
<listOfModifiers/>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci>KKp</ci>
<ci>V6</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>KK6</ci>
<ci>KKp</ci>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="V6"
value="0.75"/>
<parameter id="KK6"
value="15"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="reaction7"
name="reaction7"
reversible="false"
fast="false">
<listOfReactants>
<speciesReference species="K"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Kp"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="KKpp"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci>K</ci>
<ci>k7</ci>
<ci>KKpp</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>K</ci>
<ci>KK7</ci>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="k7"
value="0.025"/>
<parameter id="KK7"
value="15"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="reaction8"
name="reaction8"
reversible="false"
fast="false">
<listOfReactants>
<speciesReference species="Kp"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Kpp"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="KKpp"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci>k8</ci>
<ci>KKpp</ci>
<ci>Kp</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>KK8</ci>
<ci>Kp</ci>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="k8"
value="0.025"/>
<parameter id="KK8"
value="15"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="reaction9"
name="reaction9"
reversible="false"
fast="false">
<listOfReactants>
<speciesReference species="Kpp"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="Kp"/>
</listOfProducts>
<listOfModifiers/>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci>Kpp</ci>
<ci>V9</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>KK9</ci>
<ci>Kpp</ci>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="V9"
value="0.5"/>
<parameter id="KK9"
value="15"/>
</listOfParameters>
</kineticLaw>
</reaction>
<reaction id="reaction10"
name="reaction10"
reversible="false"
fast="false">
<listOfReactants>
<speciesReference species="Kp"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="K"/>
</listOfProducts>
<listOfModifiers/>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci>Kp</ci>
<ci>V10</ci>
<apply>
<power/>
<apply>
<plus/>
<ci>KK10</ci>
<ci>Kp</ci>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
</math>
<listOfParameters>
<parameter id="V10"
value="0.5"/>
<parameter id="KK10"
value="15"/>
</listOfParameters>
</kineticLaw>
</reaction>
</listOfReactions>
<listOfEvents/>
</model>
</sbml>