<?xml version="1.0" encoding="UTF-8"?>
<!-- Generated 26-November-2003 10:15:32.996435 -->
<!-- Generated by MathSBML 2.2.1-beta-9 (25 Nov 2003) -->
<sbml xmlns="http://www.sbml.org/sbml/level2"
level="2"
version="1">
<model id="repressilator"
name="Repressilator Model">
<listOfFunctionDefinitions/>
<listOfUnitDefinitions/>
<listOfCompartments>
<compartment id="cell"
name="cell"/>
</listOfCompartments>
<listOfSpecies>
<species id="x"
name="x"
compartment="cell"
boundaryCondition="false"
constant="false"/>
<species id="y"
name="y"
compartment="cell"
boundaryCondition="false"
constant="false"/>
<species id="z"
name="z"
compartment="cell"
boundaryCondition="false"
constant="false"/>
<species id="py"
name="py"
compartment="cell"
boundaryCondition="false"
constant="false"/>
<species id="px"
name="px"
compartment="cell"
boundaryCondition="false"
constant="false"
initialAmount="5"/>
<species id="pz"
name="pz"
compartment="cell"
boundaryCondition="false"
constant="false"
initialAmount="15"/>
<species id="null"
name="null"
compartment="cell"
boundaryCondition="true"
constant="true"/>
</listOfSpecies>
<listOfParameters>
<parameter id="alpha"
name="alpha"
value="250"/>
<parameter id="beta"
name="beta"
value="5"/>
<parameter id="alpha0"
name="alpha0"
value="0"/>
<parameter id="alpha1"
name="alpha1"
value="0"/>
<parameter id="n"
name="n"
value="2.1"/>
<parameter id="k1"
name="k1"
value="1"/>
<parameter id="K"
name="K"
value="1"/>
</listOfParameters>
<listOfRules/>
<listOfReactions>
<reaction id="reaction1"
name="reaction1"
reversible="true"
fast="false">
<listOfReactants>
<speciesReference species="null"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="x"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="pz"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci>alpha0</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha1</ci>
<apply>
<power/>
<ci>pz</ci>
<ci>n</ci>
</apply>
</apply>
<ci>alpha</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<ci>K</ci>
<ci>n</ci>
</apply>
<apply>
<power/>
<ci>pz</ci>
<ci>n</ci>
</apply>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer">-1</cn>
<apply>
<times/>
<ci>k1</ci>
<ci>x</ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters/>
</kineticLaw>
</reaction>
<reaction id="reaction2"
name="reaction2"
reversible="true"
fast="false">
<listOfReactants>
<speciesReference species="null"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="y"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="px"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci>alpha0</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha1</ci>
<apply>
<power/>
<ci>px</ci>
<ci>n</ci>
</apply>
</apply>
<ci>alpha</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<ci>K</ci>
<ci>n</ci>
</apply>
<apply>
<power/>
<ci>px</ci>
<ci>n</ci>
</apply>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer">-1</cn>
<apply>
<times/>
<ci>k1</ci>
<ci>y</ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters/>
</kineticLaw>
</reaction>
<reaction id="reaction3"
name="reaction3"
reversible="true"
fast="false">
<listOfReactants>
<speciesReference species="null"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="z"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="py"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<ci>alpha0</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha1</ci>
<apply>
<power/>
<ci>py</ci>
<ci>n</ci>
</apply>
</apply>
<ci>alpha</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<ci>K</ci>
<ci>n</ci>
</apply>
<apply>
<power/>
<ci>py</ci>
<ci>n</ci>
</apply>
</apply>
<cn type="integer">-1</cn>
</apply>
</apply>
<apply>
<times/>
<cn type="integer">-1</cn>
<apply>
<times/>
<ci>k1</ci>
<ci>z</ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters/>
</kineticLaw>
</reaction>
<reaction id="reaction4"
name="reaction4"
reversible="true"
fast="false">
<listOfReactants>
<speciesReference species="px"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="null"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="x"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<times/>
<cn type="integer">-1</cn>
<ci>beta</ci>
</apply>
<apply>
<plus/>
<ci>x</ci>
<apply>
<times/>
<cn type="integer">-1</cn>
<ci>px</ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters/>
</kineticLaw>
</reaction>
<reaction id="reaction5"
name="reaction5"
reversible="true"
fast="false">
<listOfReactants>
<speciesReference species="py"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="null"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="y"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<times/>
<cn type="integer">-1</cn>
<ci>beta</ci>
</apply>
<apply>
<plus/>
<ci>y</ci>
<apply>
<times/>
<cn type="integer">-1</cn>
<ci>py</ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters/>
</kineticLaw>
</reaction>
<reaction id="reaction6"
name="reaction6"
reversible="true"
fast="false">
<listOfReactants>
<speciesReference species="pz"/>
</listOfReactants>
<listOfProducts>
<speciesReference species="null"/>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference species="z"/>
</listOfModifiers>
<kineticLaw timeUnits="time"
substanceUnits="substance">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<times/>
<cn type="integer">-1</cn>
<ci>beta</ci>
</apply>
<apply>
<plus/>
<ci>z</ci>
<apply>
<times/>
<cn type="integer">-1</cn>
<ci>pz</ci>
</apply>
</apply>
</apply>
</math>
<listOfParameters/>
</kineticLaw>
</reaction>
</listOfReactions>
<listOfEvents/>
</model>
</sbml>