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		<notes>
			<p>This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2006 The BioModels Team.<br /> For more information see the <a href="http://www.ebi.ac.uk/biomodels/legal.html">terms of use</a>.</p>
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			<species metaid="_584615" id="MAPK_PP" name="MAPK-PP" compartment="uVol" initialConcentration="10">
				<annotation>
					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
						<rdf:Description rdf:about="#_584615">
							<bqbiol:isVersionOf>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.uniprot.org/#P26696" />

								</rdf:Bag>
							</bqbiol:isVersionOf>
						</rdf:Description>
					</rdf:RDF>
				</annotation>
			</species>
		</listOfSpecies>
		<listOfReactions>
			<reaction metaid="_584635" id="J0" name="MAPKKK activation" reversible="false">

				<annotation>
					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
						<rdf:Description rdf:about="#_584635">
							<bqbiol:isVersionOf>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.ec-code.org/#2.7.11.1" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0000185" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0008349" />
								</rdf:Bag>

							</bqbiol:isVersionOf>
							<bqbiol:isHomologTo>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.reactome.org/#REACT_525" />
								</rdf:Bag>
							</bqbiol:isHomologTo>
						</rdf:Description>
					</rdf:RDF>
				</annotation>

				<listOfReactants>
					<speciesReference species="MKKK" />
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="MKKK_P" />
				</listOfProducts>
				<listOfModifiers>
					<modifierSpeciesReference species="MAPK_PP" />
				</listOfModifiers>

				<kineticLaw>
					<math xmlns="http://www.w3.org/1998/Math/MathML">
						<apply>
							<divide />
							<apply>
								<times />
								<ci> uVol </ci>
								<ci> V1 </ci>

								<ci> MKKK </ci>
							</apply>
							<apply>
								<times />
								<apply>
									<plus />
									<cn type="integer"> 1 </cn>

									<apply>
										<power />
										<apply>
											<divide />
											<ci> MAPK_PP </ci>
											<ci> Ki </ci>
										</apply>

										<ci> n </ci>
									</apply>
								</apply>
								<apply>
									<plus />
									<ci> K1 </ci>
									<ci> MKKK </ci>

								</apply>
							</apply>
						</apply>
					</math>
					<listOfParameters>
						<parameter id="V1" value="2.5" />
						<parameter id="Ki" value="9" />
						<parameter id="n" value="1" />
						<parameter id="K1" value="10" />

					</listOfParameters>
				</kineticLaw>
			</reaction>
			<reaction metaid="_584655" id="J1" name="MAPKKK inactivation" reversible="false">
				<annotation>
					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
						<rdf:Description rdf:about="#_584655">
							<bqbiol:isVersionOf>
								<rdf:Bag>

									<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#3.1.3.16" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006470" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0051390" />
								</rdf:Bag>
							</bqbiol:isVersionOf>
						</rdf:Description>
					</rdf:RDF>
				</annotation>
				<listOfReactants>

					<speciesReference species="MKKK_P" />
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="MKKK" />
				</listOfProducts>
				<kineticLaw>
					<math xmlns="http://www.w3.org/1998/Math/MathML">
						<apply>
							<divide />

							<apply>
								<times />
								<ci> uVol </ci>
								<ci> V2 </ci>
								<ci> MKKK_P </ci>
							</apply>

							<apply>
								<plus />
								<ci> KK2 </ci>
								<ci> MKKK_P </ci>
							</apply>
						</apply>
					</math>

					<listOfParameters>
						<parameter id="V2" value="0.25" />
						<parameter id="KK2" value="8" />
					</listOfParameters>
				</kineticLaw>
			</reaction>
			<reaction metaid="_584675" id="J2" name="phosphorylation of MAPKK" reversible="false">
				<annotation>
					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">

						<rdf:Description rdf:about="#_584675">
							<bqbiol:isVersionOf>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.ec-code.org/#2.7.11.25" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006468" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0004709" />
								</rdf:Bag>
							</bqbiol:isVersionOf>
							<bqbiol:isHomologTo>

								<rdf:Bag>
									<rdf:li rdf:resource="http://www.reactome.org/#REACT_614" />
								</rdf:Bag>
							</bqbiol:isHomologTo>
						</rdf:Description>
					</rdf:RDF>
				</annotation>
				<listOfReactants>
					<speciesReference species="MKK" />

				</listOfReactants>
				<listOfProducts>
					<speciesReference species="MKK_P" />
				</listOfProducts>
				<listOfModifiers>
					<modifierSpeciesReference species="MKKK_P" />
				</listOfModifiers>
				<kineticLaw>
					<math xmlns="http://www.w3.org/1998/Math/MathML">

						<apply>
							<divide />
							<apply>
								<times />
								<ci> uVol </ci>
								<ci> k3 </ci>
								<ci> MKKK_P </ci>

								<ci> MKK </ci>
							</apply>
							<apply>
								<plus />
								<ci> KK3 </ci>
								<ci> MKK </ci>

							</apply>
						</apply>
					</math>
					<listOfParameters>
						<parameter id="k3" value="0.025" />
						<parameter id="KK3" value="15" />
					</listOfParameters>
				</kineticLaw>
			</reaction>

			<reaction metaid="_584695" id="J3" name="phosphorylation of MAPKK-P" reversible="false">
				<annotation>
					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
						<rdf:Description rdf:about="#_584695">
							<bqbiol:isVersionOf>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.ec-code.org/#2.7.11.25" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0004709" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006468" />

									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0000186" />
								</rdf:Bag>
							</bqbiol:isVersionOf>
							<bqbiol:isHomologTo>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.reactome.org/#REACT_614" />
								</rdf:Bag>
							</bqbiol:isHomologTo>
						</rdf:Description>

					</rdf:RDF>
				</annotation>
				<listOfReactants>
					<speciesReference species="MKK_P" />
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="MKK_PP" />
				</listOfProducts>
				<listOfModifiers>

					<modifierSpeciesReference species="MKKK_P" />
				</listOfModifiers>
				<kineticLaw>
					<math xmlns="http://www.w3.org/1998/Math/MathML">
						<apply>
							<divide />
							<apply>
								<times />
								<ci> uVol </ci>

								<ci> k4 </ci>
								<ci> MKKK_P </ci>
								<ci> MKK_P </ci>
							</apply>
							<apply>
								<plus />

								<ci> KK4 </ci>
								<ci> MKK_P </ci>
							</apply>
						</apply>
					</math>
					<listOfParameters>
						<parameter id="k4" value="0.025" />

						<parameter id="KK4" value="15" />
					</listOfParameters>
				</kineticLaw>
			</reaction>
			<reaction metaid="_584715" id="J4" name="dephosphorylation of MAPKK-PP" reversible="false">
				<annotation>
					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
						<rdf:Description rdf:about="#_584715">
							<bqbiol:isVersionOf>

								<rdf:Bag>
									<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#3.1.3.16" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006470" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0051389" />
								</rdf:Bag>
							</bqbiol:isVersionOf>
						</rdf:Description>
					</rdf:RDF>
				</annotation>

				<listOfReactants>
					<speciesReference species="MKK_PP" />
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="MKK_P" />
				</listOfProducts>
				<kineticLaw>
					<math xmlns="http://www.w3.org/1998/Math/MathML">
						<apply>

							<divide />
							<apply>
								<times />
								<ci> uVol </ci>
								<ci> V5 </ci>
								<ci> MKK_PP </ci>

							</apply>
							<apply>
								<plus />
								<ci> KK5 </ci>
								<ci> MKK_PP </ci>
							</apply>
						</apply>

					</math>
					<listOfParameters>
						<parameter id="V5" value="0.75" />
						<parameter id="KK5" value="15" />
					</listOfParameters>
				</kineticLaw>
			</reaction>
			<reaction metaid="_584735" id="J5" name="dephosphorylation of MAPKK-P" reversible="false">
				<annotation>

					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
						<rdf:Description rdf:about="#_584735">
							<bqbiol:isVersionOf>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#3.1.3.16" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006470" />
								</rdf:Bag>
							</bqbiol:isVersionOf>
						</rdf:Description>

					</rdf:RDF>
				</annotation>
				<listOfReactants>
					<speciesReference species="MKK_P" />
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="MKK" />
				</listOfProducts>
				<kineticLaw>

					<math xmlns="http://www.w3.org/1998/Math/MathML">
						<apply>
							<divide />
							<apply>
								<times />
								<ci> uVol </ci>
								<ci> V6 </ci>

								<ci> MKK_P </ci>
							</apply>
							<apply>
								<plus />
								<ci> KK6 </ci>
								<ci> MKK_P </ci>

							</apply>
						</apply>
					</math>
					<listOfParameters>
						<parameter id="V6" value="0.75" />
						<parameter id="KK6" value="15" />
					</listOfParameters>
				</kineticLaw>
			</reaction>

			<reaction metaid="_584755" id="J6" name="phosphorylation of MAPK" reversible="false">
				<annotation>
					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
						<rdf:Description rdf:about="#_584755">
							<bqbiol:isVersionOf>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.ec-code.org/#2.7.12.2" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0004708" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006468" />

								</rdf:Bag>
							</bqbiol:isVersionOf>
							<bqbiol:hasVersion>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.reactome.org/#REACT_136" />
									<rdf:li rdf:resource="http://www.reactome.org/#REACT_2247" />
								</rdf:Bag>
							</bqbiol:hasVersion>
						</rdf:Description>

					</rdf:RDF>
				</annotation>
				<listOfReactants>
					<speciesReference species="MAPK" />
				</listOfReactants>
				<listOfProducts>
					<speciesReference species="MAPK_P" />
				</listOfProducts>
				<listOfModifiers>

					<modifierSpeciesReference species="MKK_PP" />
				</listOfModifiers>
				<kineticLaw>
					<math xmlns="http://www.w3.org/1998/Math/MathML">
						<apply>
							<divide />
							<apply>
								<times />
								<ci> uVol </ci>

								<ci> k7 </ci>
								<ci> MKK_PP </ci>
								<ci> MAPK </ci>
							</apply>
							<apply>
								<plus />

								<ci> KK7 </ci>
								<ci> MAPK </ci>
							</apply>
						</apply>
					</math>
					<listOfParameters>
						<parameter id="k7" value="0.025" />

						<parameter id="KK7" value="15" />
					</listOfParameters>
				</kineticLaw>
			</reaction>
			<reaction metaid="_584775" id="J7" name="phosphorylation of MAPK-P" reversible="false">
				<annotation>
					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
						<rdf:Description rdf:about="#_584775">
							<bqbiol:isVersionOf>

								<rdf:Bag>
									<rdf:li rdf:resource="http://www.ec-code.org/#2.7.12.2" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006468" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0004708" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0000187" />
								</rdf:Bag>
							</bqbiol:isVersionOf>
							<bqbiol:hasVersion>
								<rdf:Bag>

									<rdf:li rdf:resource="http://www.reactome.org/#REACT_136" />
									<rdf:li rdf:resource="http://www.reactome.org/#REACT_2247" />
								</rdf:Bag>
							</bqbiol:hasVersion>
						</rdf:Description>
					</rdf:RDF>
				</annotation>
				<listOfReactants>
					<speciesReference species="MAPK_P" />

				</listOfReactants>
				<listOfProducts>
					<speciesReference species="MAPK_PP" />
				</listOfProducts>
				<listOfModifiers>
					<modifierSpeciesReference species="MKK_PP" />
				</listOfModifiers>
				<kineticLaw>
					<math xmlns="http://www.w3.org/1998/Math/MathML">

						<apply>
							<divide />
							<apply>
								<times />
								<ci> uVol </ci>
								<ci> k8 </ci>
								<ci> MKK_PP </ci>

								<ci> MAPK_P </ci>
							</apply>
							<apply>
								<plus />
								<ci> KK8 </ci>
								<ci> MAPK_P </ci>

							</apply>
						</apply>
					</math>
					<listOfParameters>
						<parameter id="k8" value="0.025" />
						<parameter id="KK8" value="15" />
					</listOfParameters>
				</kineticLaw>
			</reaction>

			<reaction metaid="_584795" id="J8" name="dephosphorylation of MAPK-PP" reversible="false">
				<annotation>
					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
						<rdf:Description rdf:about="#_584795">
							<bqbiol:isVersionOf>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#3.1.3.16" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006470" />
									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0000188" />

								</rdf:Bag>
							</bqbiol:isVersionOf>
						</rdf:Description>
					</rdf:RDF>
				</annotation>
				<listOfReactants>
					<speciesReference species="MAPK_PP" />
				</listOfReactants>
				<listOfProducts>

					<speciesReference species="MAPK_P" />
				</listOfProducts>
				<kineticLaw>
					<math xmlns="http://www.w3.org/1998/Math/MathML">
						<apply>
							<divide />
							<apply>
								<times />
								<ci> uVol </ci>

								<ci> V9 </ci>
								<ci> MAPK_PP </ci>
							</apply>
							<apply>
								<plus />
								<ci> KK9 </ci>

								<ci> MAPK_PP </ci>
							</apply>
						</apply>
					</math>
					<listOfParameters>
						<parameter id="V9" value="0.5" />
						<parameter id="KK9" value="15" />
					</listOfParameters>

				</kineticLaw>
			</reaction>
			<reaction metaid="_584815" id="J9" name="dephosphorylation of MAPK-P" reversible="false">
				<annotation>
					<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
						<rdf:Description rdf:about="#_584815">
							<bqbiol:isVersionOf>
								<rdf:Bag>
									<rdf:li rdf:resource="http://www.ebi.ac.uk/IntEnz/#3.1.3.16" />

									<rdf:li rdf:resource="http://www.geneontology.org/#GO:0006470" />
								</rdf:Bag>
							</bqbiol:isVersionOf>
						</rdf:Description>
					</rdf:RDF>
				</annotation>
				<listOfReactants>
					<speciesReference species="MAPK_P" />
				</listOfReactants>

				<listOfProducts>
					<speciesReference species="MAPK" />
				</listOfProducts>
				<kineticLaw>
					<math xmlns="http://www.w3.org/1998/Math/MathML">
						<apply>
							<divide />
							<apply>
								<times />

								<ci> uVol </ci>
								<ci> V10 </ci>
								<ci> MAPK_P </ci>
							</apply>
							<apply>
								<plus />

								<ci> KK10 </ci>
								<ci> MAPK_P </ci>
							</apply>
						</apply>
					</math>
					<listOfParameters>
						<parameter id="V10" value="0.5" />

						<parameter id="KK10" value="15" />
					</listOfParameters>
				</kineticLaw>
			</reaction>
		</listOfReactions>
	</model>
</sbml>
